Sjogren Syndrome (also Sjogren’s Syndrome)

The disease was first identified in 1933 by Dr. Henrik Sjogren. Sjogren’s syndrome occurs across all racial and ethnic groups. General awareness about Sjogren’s syndrome is still lacking, even among physicians.

Sjogren’s Syndrome Facts

• Sjogren’s syndrome is an autoimmune disease.
• Sjogren’s syndrome involves inflammation of glands (in particular glands within the eye and mouth) and other issues of the body.
• About 90% of Sjogren’s syndrome patients are female.
• Sjogren’s syndrome can be complicated by infections of the eyes, breathing passages, and mouth.
• Sjogren’s syndrome is typically associated with antibodies against a variety of body tissues (auto antibodies).
• Diagnosis of Sjogren’s syndrome can be confirmed with a saliva-gland biopsy.
• Treatment of patients with Sjogren’s syndrome is directed toward the particular areas of the body that are involved and toward any existing complications, such as infections.
• Sjogrens syndrome is one of the most prevalent autoimmune disorders.

Click on any of the links to the right to learn more.

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References

1. Kaneko Y. [Diagnostic (Classification) Criteria and Treatment Guidelines of Collagen-vascular Diseases: Hos to Use and Cautions on Applying Them for General Physicians. Topics: VII. Sjögren Syndrome]. Nihon Naika Gakkai Zasshi. 2015 Oct;104(10):2149-56. [PubMed]

2. Brito-Zerón P, Retamozo S, Ramos-Casals M. Phenotyping Sjögren’s syndrome: towards a personalised management of the disease. Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):198-209. [PubMed]

3. Argyropoulou OD, Valentini E, Ferro F, Leone MC, Cafaro G, Bartoloni E, Baldini C. One year in review 2018: Sjögren’s syndrome. Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):14-26. [PubMed]

4. Baer AN, Akpek EK, Alevizos I., 18-21 April 2018, Washington, DC, USA. 14th International Symposium on Sjögren’s Syndrome. Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):241-255. [PubMed]

5. Kroese FGM, Haacke EA, Bombardieri M. The role of salivary gland histopathology in primary Sjögren’s syndrome: promises and pitfalls. Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):222-233. [PubMed]

6. Kiadaliri AA, Mohammad AJ, Englund M. Hospitalizations due to systemic connective tissue diseases: Secular trends and regional disparities in Sweden, 1998-2016. Int J Rheum Dis. 2018 Nov;21(11):1900-1906. [PubMed]

7. Alani H, Henty JR, Thompson NL, Jury E, Ciurtin C. Systematic review and meta-analysis of the epidemiology of polyautoimmunity in Sjögren’s syndrome (secondary Sjögren’s syndrome) focusing on autoimmune rheumatic diseases. Scand J Rheumatol. 2018 Mar;47(2):141-154. [PubMed]

8. Bunya VY, Fernandez KB, Ying GS, Massaro-Giordano M, Macchi I, Sulewski ME, Hammersmith KM, Nagra PK, Rapuano CJ, Orlin SE. Survey of Ophthalmologists Regarding Practice Patterns for Dry Eye and Sjogren Syndrome. Eye Contact Lens. 2018 Nov;44 Suppl 2(Suppl 2):S196-S201. [PMC free article] [PubMed]

9. Tzioufas AG, Goules AV. Limited efficacy of targeted treatments in Sjögren’s syndrome: why? Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):27-28. [PubMed]

10. De Vita S, Gandolfo S, Zandonella Callegher S, Zabotti A, Quartuccio L. The evaluation of disease activity in Sjögren’s syndrome based on the degree of MALT involvement: glandular swelling and cryoglobulinaemia compared to ESSDAI in a cohort study. Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):150-156. [PubMed]